Footwear industry is labour intensive that significantly supports the economic development of Indonesia for more than a decade. In the production process, however, thousands of workers are exposed to various occupational hazard. The present study explores th eimplementation of safety aspects in a footwear industry, which was indicated by the number of accidents during 2008-2011 period and the workplace conditions. Following our visits and discussions with the member of the industry, it was noted that in 2008 and 2009 there were respectively 131 and 122 accidents. In 2010 showed a significantly increased to 165 accidents. It seems that due to management interventions, the number of accidents in 2011 were drastically reduced to 56. To improve safety, the occupational hazard in the workplace has to be eliminated. Data on the adverse health effects of the workers was not available. This fact is mainly due to improper awareness management of the occupational health. It is suggested that the occupational health and safety will be improved by developing system approach, i.e. participative macroergonomics. The macroergonomics is an approach supported by the management, that take into account huma condition with regard to organizational, social and technological contexts.